Polypoidal choroidal vasculopathy: Insights from quantitative OCT-Angiography

Session Details

Session Title: Free Paper Session 21: Imaging III

Session Date/Time: Sunday 10/09/2017 | 08:00-09:30

Paper Time: 08:48

Venue: Room 113

First Author: : M.Raimundo PORTUGAL

Co Author(s): :    A. Martins   J. Marques   C. Farinha   M. Cachulo   J. Cunha Vaz   R. Silva              

Abstract Details


To evaluate quantitative changes in the vascular network in eyes with polypoidal choroidal vasculopathy (PCV), both affected and fellow eyes, using optical coherence tomography angiography (OCT-A).


Ophthalmology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal. Association for Innovation and Biomedical Research on Light and Image (AIBILI), Coimbra, Portugal. Faculty of Medicine, University of Coimbra, Portugal (FMUC).


Cross-sectional study with 4 study groups: controls (44 eyes), early/intermediate AMD (30 eyes), PCV fellow eyes (7 eyes) and PCV (10 eyes). We used the Cirrus 5000 AngioPlex (Zeiss, Dublin, California, USA) to obtain 3x3 mm OCT-A images to quantitatively evaluate the vascular perfusion of the superficial retinal plexus, deep retinal plexus, and choriocapillaris. To test for statistically significant differences between groups, the Kruskal Wallis test was used, followed by the Dunn post-hoc test to assess pairwise comparisons and direction of effects.


We have found that superficial plexus perfusion density was lower in both affected and fellow PCV eyes when compared to the other groups (all p<0.001), while perfusion density did not differ between them or between controls and early/intermediate AMD. On the other hand, perfusion density at the deep retinal plexus level did not differ between groups. At the choriocapillaris level, while no differences were seen between control and early/intermediate AMD eyes, an ordered and significant decrease in perfusion density was seen for all the other groups (early/intermediate AMD > PCV fellow eyes > PCV eyes, all p<0.001 in paired between groups comparisons).


To the best of our knowledge this is the first study to look at PCV and the fellow eye of PCV using quantitative OCT-Angiography. We have found evidence of a distinct and more atrophic vascular phenotype in the fellow-eye of PCV, with reduced perfusion density in the superficial retinal plexus and choriocapillaris, while conspicuously sparing the deep retinal plexus, even when compared to early/intermediate AMD eyes.

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