Evaluation of foveal avascular zone in Alzheimer’s type dementia with OCT-A

Session Details

Session Title: Free Paper Session 21: Imaging III

Session Date/Time: Sunday 10/09/2017 | 08:00-09:30

Paper Time: 08:30

Venue: Room 113

First Author: : M.K.Erol TURKEY

Co Author(s): :    M. Bulut   F. Kurtulus   O. Gozkaya   A. Cenzig   M. Akidan                 

Abstract Details


To identify foveal avascular zone pathologies in patients with Alzheimer’s type dementia (ATD) through optical coherence tomography angiography (OCT-A) imaging.


Department of Ophthalmology, Antalya Training and Research Hospital, University of Health Sciences, Antalya, Turkey


Our study included 26 patients as the patient group and age and sex matched 26 subjects in the control group. A detailed ophthalmological and neurological examination was performed for all subjects included in the study. The foveal avascular zone areas were analyzed in a detailed way with a commercial spectral domain OCT-A. Moreover, all participants underwent detailed neurological examination including mini mental state examination (MMSE) test to evaluate the cognitive function.


In ATD patients group, the MMSE score was significantly lower than that of the control group (p<0.001). Foveal avascular zone (FAZ) was significantly enlarged compared to the control group (p=0.001). Furthermore, significant correlation was found between the MMSE and FAZ tested with OCT-A imaging (p<0.001).


In ATD patients, foveal avascular zone through OCT-A imaging can be used as a new biomarker in the early diagnosis of the disease, follow-up of its progression and in investigating the efficacy of the drugs.

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