Evaluation of foveal avascular zone in Alzheimer’s type dementia with OCT-A

Session Details

Session Title: Free Paper Session 21: Imaging III

Session Date/Time: Sunday 10/09/2017 | 08:00-09:30

Paper Time: 08:30

Venue: Room 113

First Author: : M.K.Erol TURKEY

Co Author(s): :    M. Bulut   F. Kurtulus   O. Gozkaya   A. Cenzig   M. Akidan                 

Abstract Details

Purpose:

To identify foveal avascular zone pathologies in patients with Alzheimer’s type dementia (ATD) through optical coherence tomography angiography (OCT-A) imaging.

Setting:

Department of Ophthalmology, Antalya Training and Research Hospital, University of Health Sciences, Antalya, Turkey

Methods:

Our study included 26 patients as the patient group and age and sex matched 26 subjects in the control group. A detailed ophthalmological and neurological examination was performed for all subjects included in the study. The foveal avascular zone areas were analyzed in a detailed way with a commercial spectral domain OCT-A. Moreover, all participants underwent detailed neurological examination including mini mental state examination (MMSE) test to evaluate the cognitive function.

Results:

In ATD patients group, the MMSE score was significantly lower than that of the control group (p<0.001). Foveal avascular zone (FAZ) was significantly enlarged compared to the control group (p=0.001). Furthermore, significant correlation was found between the MMSE and FAZ tested with OCT-A imaging (p<0.001).

Conclusions:

In ATD patients, foveal avascular zone through OCT-A imaging can be used as a new biomarker in the early diagnosis of the disease, follow-up of its progression and in investigating the efficacy of the drugs.

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