Comparative study of combined vitrectomy/ranibizumab vs vitrectomy alone for diabetic macular edema: Preliminary results

Session Details

Session Title: Free Paper Session 20: Vitreoretinal Surgery V

Session Date/Time: Sunday 10/09/2017 | 08:00-09:30

Paper Time: 08:00

Venue: Room 117

First Author: : R.Zainullin RUSSIA

Co Author(s): :    M. Bikbov   R. Fayzrakhmanov   V. Salavatova   M. Kalanov                    

Abstract Details


To evaluate the results of treatment of diabetic macular edema using a combined vitrectomy/ranibizumab and only vitrectomy as monotherapy.


Ufa Eye Research Institute, Ufa, Russia


We operated 32 patients with diabetic macular edema in conjunction with vitreomacular traction syndrome. Group A consisted of 16 patients (16 eyes), who received a seamless pars plana vitrectomy (PPV) with peeling of the internal limiting membrane (ILM) using systems 25g. After the surgery, they were intravitrealy injected with ranibizumab 0.5 mg (IVR). Group B included 16 patients (16 eyes), who received only PPV with ILM peeling. Results were evaluated in 1 month after the surgery. The structural changes of the retina were analyzed with the use of the optical coherence tomography with a high resolution, swept-source OCT


In Group A, the best corrected visual acuity (BCVA), after the combined treatment, was 0.54 ± 0.15 LogMAR, on average, while group B had BCVA equal to 0.71 LogMAR (P = 0.047), on average. In Group A , based on the data of the optical coherence tomography the thickness of the retina in the area of fovea was 365.39 ± 12.34 µm, on average; in group B, 399.26 ± 13.24 µm (p = 0.032). However, we observed the preservation of some edema in the outer and inner retinal layer, inner nuclear layer, and partly in the layer of ganglion cells in 35.3% of patients In Group A and 48.7% in Group B.


The combined therapy including PPV with ILM peeling with IVR demonstrates the best anatomical and functional results, in particular: the improvement of visual acuity and decrease of the thickness of the central area of the retina in patients with diabetic macular edema, combined with traction syndrome.

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