Evaluation of adult-onset foveomacular vitelliform dystrophy using optical coherence tomography angiography and swept-source optical coherence tomography

Session Details

Session Title: Free Paper Session 17: Imaging II

Session Date/Time: Saturday 09/09/2017 | 08:00-09:30

Paper Time: 08:24

Venue: Room 120

First Author: : I.Pires PORTUGAL

Co Author(s): :                                 

Abstract Details

Purpose:

To evaluate vascular abnormalities and choroidal thickness (CT) in eyes with adult-onset foveomacular vitelliform dystrophy (AOFVD) using noninvasive methods: swept-source optical coherence tomography (SS-OCT) and optical coherence tomography angiography (OCT-A).

Setting:

Clinical medical retina from Department of Ophthalmology, Centro Hospitalar e Universitário de Coimbra (CHUC), EPE, and Association for Innovation and Biomedical Research on Light and Image (AIBILI), Coimbra, Portugal.

Methods:

Cross sectional study of patients with AOFVD diagnosis using OCT-A (Zeiss Cirrus 5000 AngioPlex system or Optovue RTVue XR Avanti AngioVue system) and SS-OCT (Topcon DRI OCT-1 Atlantis) systems. Eyes with AOFVD were divided in 3 stages, based on OCT characteristics: vitelliform, pseudohypopyon and vitelliruptive; eyes with atrophic/fibrotic stage were excluded. Macular vascular morphology and abnormalities were evaluated on en face OCT-A images. Retinal thickness (RT) and CT maps were obtained in the macula with automated software (ETDRS grid, 9 fields); the mean CT (mean value within ETDRS grid), and central RT and CT (central 1mm area), were calculated.

Results:

Twenty six eyes from 20 patients with AOFVD diagnosis were included in the analysis (11 man and 9 woman, mean age±SD of 76,62±6,78). AOFVD was bilateral in 6 patients; 18 eyes presented vitelliform stage, 7 pseudohypopyon and 1 vitelliruptive; mean BCVA in the study eyes was 20/50. On OCT-A images, the presence of subretinal vitelliform material was associated with variable degree of vascular displacement and rarefaction, both in the superficial and deep capillary plexus of the retina; in one eye an image suggestive of CNV at the choriocapillaris level was observed. Mean CT and mean central CT were 194,75±93,21 and 200,19±93,09, respectively. Mean CT was, in descending order, higher in superior and temporal subfields, followed by nasal and inferior subfields (all p<0.05). Central choroidal thickness did not correlate with central retinal thickness (p>0.05).

Conclusions:

OCT-A images show frequent vascular abnormalities in the central macula in eyes with AOFVD - displacement and rarefaction, in the retinal plexus, and presumed CNV, in the choriocapillaris, thus allowing a noninvasive evaluation of the retinal and choroidal microvasculature in this patients. In this study we didn’t found subfoveal choroidal thickening.

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