Session Title: Free Paper Session 17: Imaging II
Session Date/Time: Saturday 09/09/2017 | 08:00-09:30
Paper Time: 08:24
Venue: Room 120
First Author: : I.Pires PORTUGAL
Co Author(s): :
To evaluate vascular abnormalities and choroidal thickness (CT) in eyes with adult-onset foveomacular vitelliform dystrophy (AOFVD) using noninvasive methods: swept-source optical coherence tomography (SS-OCT) and optical coherence tomography angiography (OCT-A).
Clinical medical retina from Department of Ophthalmology, Centro Hospitalar e Universitário de Coimbra (CHUC), EPE, and Association for Innovation and Biomedical Research on Light and Image (AIBILI), Coimbra, Portugal.
Cross sectional study of patients with AOFVD diagnosis using OCT-A (Zeiss Cirrus 5000 AngioPlex system or Optovue RTVue XR Avanti AngioVue system) and SS-OCT (Topcon DRI OCT-1 Atlantis) systems. Eyes with AOFVD were divided in 3 stages, based on OCT characteristics: vitelliform, pseudohypopyon and vitelliruptive; eyes with atrophic/fibrotic stage were excluded. Macular vascular morphology and abnormalities were evaluated on en face OCT-A images. Retinal thickness (RT) and CT maps were obtained in the macula with automated software (ETDRS grid, 9 fields); the mean CT (mean value within ETDRS grid), and central RT and CT (central 1mm area), were calculated.
Twenty six eyes from 20 patients with AOFVD diagnosis were included in the analysis (11 man and 9 woman, mean age±SD of 76,62±6,78). AOFVD was bilateral in 6 patients; 18 eyes presented vitelliform stage, 7 pseudohypopyon and 1 vitelliruptive; mean BCVA in the study eyes was 20/50. On OCT-A images, the presence of subretinal vitelliform material was associated with variable degree of vascular displacement and rarefaction, both in the superficial and deep capillary plexus of the retina; in one eye an image suggestive of CNV at the choriocapillaris level was observed. Mean CT and mean central CT were 194,75±93,21 and 200,19±93,09, respectively. Mean CT was, in descending order, higher in superior and temporal subfields, followed by nasal and inferior subfields (all p<0.05). Central choroidal thickness did not correlate with central retinal thickness (p>0.05).
OCT-A images show frequent vascular abnormalities in the central macula in eyes with AOFVD - displacement and rarefaction, in the retinal plexus, and presumed CNV, in the choriocapillaris, thus allowing a noninvasive evaluation of the retinal and choroidal microvasculature in this patients. In this study we didn’t found subfoveal choroidal thickening.