Retinal neurodegeneration and foveal avascular zone in diabetic eyes: Based on OCT-Angiography

Session Details

Session Title: Free Paper Session 16: Vascular Diseases & Diabetic Retinopathy IV

Session Date/Time: Friday 08/09/2017 | 16:30-18:00

Paper Time: 16:48

Venue: Room 114

First Author: : K.Kim SOUTH KOREA

Co Author(s): :    D. Kim   E. Kim   S. Yu                       

Abstract Details

Purpose:

To evaluate the correlation of ganglion cell-inner plexiform (GC-IPL) thickness with early microvascular changes in diabetic eyes using OCT-A (Angioplex, Carl Zeiss)

Setting:

Department of ophthalmology, Kyung Hee University Medical centre, Seoul, Republic of Korea

Methods:

Medical records of diabetic patients without retinopathy (n=70), diabetic patients with mild NPDR (n=75), and healthy eyes (n=70) were reviewed. The mean parafoveal GC- IPL thickness were measured using Cirrus HD-OCT (Carl Zeiss). The FAZ area, FAZ circularity index, and vessel density of parafovea were calculated using OCT-A

Results:

There were significant differences between diabetic groups and control regardless of retinopathy, in terms of GC-IPL thickness (both 78.8µm vs 82.7µm), area of superficial (0.39 and 0.38mm² vs 0.29mm²) and deep capillary layer (0.46 and 0.44mm² vs 0.36mm²), circularity index of FAZ (0.58 and 0.59 vs 0.65), and vessel density (both 17.1/mm vs 20/mm). In two diabetic groups, these four parameters showed significant linear correlation with GC-IPL thickness. Multivariate regression analysis resulted that FAZ area (OR=-24.2) and circularity index (OR=35.4) were proved to be strongly associated with GC-IPL thickness

Conclusions:

We found enlarged FAZ area, irregular shape of FAZ, and less parafoveal vessel in diabetic eyes regardless of retinopathy. Also retinal neurodegeneration and early microvascular changes are supposed to be correlated before visible retinopathy.

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