Surgical technique development in three animal models for a subretinal wireless chip implantation (Prima)

Session Details

Session Title: Free Paper Session 15: Mixed Session

Session Date/Time: Friday 08/09/2017 | 16:30-18:00

Paper Time: 17:18

Venue: Room 117

First Author: : M.Muqit UK

Co Author(s): :    J. Hubschman   Y. Le Mer                          

Abstract Details


To report the anatomical results of implantations of a new subretinal wireless artificial retina made of a 1.5x1.5 mm chip in different animal models to obtain a reliable technique ready for human surgery


Eye Care for Animals, Pasedena, USA Institut Montsouris, Paris, France CEA, Fontenay aux roses, France


Three different models were used with three different surgeons; 1. cats with implantation of 11 eyes to define the technique and to study long term histologic effects of chronic stimulation; 2. monkeys with surgery in 19 eyes to verify the surgical technique, the six months safety, the risks of late explantation, and in some cases the functional results ; 3. pigs eyes with 6 implantations to define an in vivo training model for surgeons.


The surgical technique was refined for all models, with tamponade of air, gas or silicone oil. We'll present only the surgical complications and anatomic results. In the whole series, the implantation was uneventful in 28 eyes. Successful chip implantation was achieved with an attached retina in 100% of cats eyes, 86% of pig eyes and 95% of monkeys eyes. Complications included: corneal ulcers in 4 cats eyes (36%), cataract formation in 2 cats (18%), vitreous haemhorrage without implantation in one pig eye (17%) and anterior uveitis with retinal detachment in 1 monkey eye (5%). In one monkey, the creation of a posterior detachment by subretinal BSS injection was not technically possible and implantation was cancelled. Mean time for implantation was 120 minutes.


Surgical implantation of a subretinal wireless chip is feasible with good anatomical results. There is a learning curve to surgery in animal models, the absence of surgical complications and successful surgery in the second training period of each animal series demonstrates that, even with experienced vitreoretinal surgeons, there is a necessity for a structured and supervised phase of training with animal model before human implantation. After sufficient surgical training, the intervention can be done without unexpectable adverse events

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