postoperative antibiotic prophylaxis following intravitreal injections

Session Details

Session Title: Free Paper Session 15: Mixed Session

Session Date/Time: Friday 08/09/2017 | 16:30-18:00

Paper Time: 17:06

Venue: Room 117

First Author: : S.Carrillo Cristancho SPAIN

Co Author(s): :    S. Copete Piqueras   L. Distefano   A. Calvo Alvarez   R. Muniz Vidal   M. Zapata Victori                 

Abstract Details


To compare the incidence of endophthalmitis after intravitreal injection (IVI) with and without home topical antibiotic prophylaxis prescription.


This study took place at the ophthalmology service of vall d'hebron hospital in Barcelona with IVI of ranibizumab, bevacizumab, and aflibercept between October 2015 and February 2017.


A retrospective cohort study of patients treated with IVI for a variety of retinal diseases (mean age of patients was 74 years old ± 11.6, range 24 to 93). All IVI were performed in an office setting, with povidone-iodine prior and after injection, and a single drop of ciprofloxacin drops 3mg/ml at the end of the procedure. There was randomized home antibiotic prescription of ciprofloxacin drops 3mg/ml 3 times a day for 5 days and controls without any antibiotic prescription.


A total of 3947 IVI were performed (2084 injections with home antibiotic prophylaxis prescription and 1863 without any antibiotic prescription), Endophthalmitis incidence in the first group was 6/2084 (0.29%), 5 cases with aflibercept and one with ranibizumab, of which only one showed culture-positive results in aqueous humor (0.047%). In the second group no cases of endophthalmitis were reported (0%). There were significant differences between the groups (Fisher test P= 0.032604).


topical antibiotic prophylaxis prescription at home the days following IVI does not reduce the risk of endophthalmitis developing. Its use should be reconsidered because of the risk of occurrence of resistance, improve the quality of life of patients to whom eye drop instillation may be difficult as well as reduce costs in public health care.

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