Radiation maculopathy after proton beam therapy for uveal melanoma: Microvascular and structural alterations influencing visual acuity

Session Details

Session Title: Free Paper Session 15: Mixed Session

Session Date/Time: Friday 08/09/2017 | 16:30-18:00

Paper Time: 16:30

Venue: Room 117

First Author: : A.Matet SWITZERLAND

Co Author(s): :    A. Daruich   L. Zografos                          

Abstract Details


To analyze microvascular and structural changes in radiation maculopathy and their influence on visual acuity (VA), using optical coherence tomography (OCT) and OCT-Angiography (OCT-A).


Retrospective observational case series from a tertiary referral centre.


Consecutive patients with radiation maculopathy, ≥12 months after proton-beam irradiation for uveal melanoma, underwent fluorescein angiography (FA), OCT and OCT-A. Low-quality OCT-A acquisitions were excluded. Clinical parameters potentially affecting VA were recorded, including OCT-A-derived metrics: foveal avascular zone (FAZ) area, vascular density and local fractal dimension of the superficial (SCP) and deep capillary plexuses (DCP). Thirty-five non-irradiated fellow eyes served as controls.


Ninety-three patients were included. FAZ was larger, SCP/DCP capillary density and local fractal dimension were lower in the 35 irradiated versus 35 fellow eyes (P<.0001). Qualitative FA microvascular alterations were correlated to FAZ area and SCP/DCP density on OCT-A (P<.01). In a univariate analysis, worse VA was associated to macular detachment at presentation (P=.024), total macular irradiation (P=.0008), higher CMT (P=.019), higher absolute CMT variation (P<.0001), cystoid edema (P=.030), ellipsoid zone disruption (P=.002), larger FAZ (P<.0001), lower SCP (P=.001) and DCP capillary density (P<.0001), and lower SCP (P=.009) and DCP local fractal dimension (P<.0001). Two multivariate models with either capillary density or fractal dimension as covariate showed that younger age (P=.014/.017), ellipsoid zone disruption (P=.034/.019), larger FAZ (P=.0006/.002), and lower DCP density (P=.008) or DCP fractal dimension (P=.012) were associated with worse VA, respectively.


VA of eyes with radiation maculopathy is influenced by several structural and microvascular factors, including FAZ area and DCP integrity.

Back to previous
EURETINA, Temple House, Temple Road, Blackrock, Co Dublin. | Phone: 00353 1 2100092 | Fax: 00353 1 2091112 | Email: euretina@euretina.org

Privacy policyHotel Terms and Conditions Cancellation policy