The bilaterality of polypoidal choroidal vasculopathy: Multimodality imaging

Session Details

Session Title: Free Paper Session 14: AMD IV

Session Date/Time: Friday 08/09/2017 | 16:30-18:00

Paper Time: 16:42

Venue: Room 111

First Author: : R.Hua CHINA

Co Author(s): :                                 

Abstract Details


To investigate the bilaterality of polypoidal choroidal vasculopathy (PCV) in Asian population, using multimodality imaging technique.


Retrospective case series study.


Diagnostic indocyanine green angiography (ICGA) and spectrum domain optical coherence tomography (SD-OCT) were performed to enrol the eligible PCV eye as study eye and its contralateral eye as fellow eye correspondingly.


Among 57 patients at baseline, 17.5% of PCV polyps were detected by OCT directly, Concerning the subfoveal choroidal thickness, the study eyes (269 [141-704] μm) was comparable to the fellow eyes (263 [161-688] μm) statistically (p=0.091). Moreover, no significant difference was observed in hyperfluorescent spots on ICGA between study eyes (84.2%) and fellow eyes (77.2%, p=0.342). On the contrary, the proportion of branching vascular network (BVN) and choroidal hyperpermeability on ICGA, retinal pigment epithelium detachment and double-layer sign on OCT in study eyes, was 89.5%, 68.4%, 94.7%, and 94.7%, thus significantly greater than in fellow eyes. In particular, two silent BVN without any leakage on both fluorescein angiography and ICGA were found in the fellow eyes.


The results indicate that the early signs of PCV in the fellow eyes were found with similar choroidal thickness on SD-OCT, hyperfluorescent dots during ICGA, compared with the PCV eyes. Furthermore, silent BVN may be secondary to pachychoroid spectrum disorders. However, whether PCV is a binocular disease or not still needs further follow up and investigation.

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