Session Title: Free Paper Session 12: Imaging I
Session Date/Time: Friday 08/09/2017 | 14:30-16:00
Paper Time: 15:48
Venue: Room 111
First Author: : F.Lai TURKEY
Co Author(s): : T. Iao D. Ng J. Leung A. Young T. Ko K. Chong
To investigate the choroidal thickness in patients with thyroid-associated orbitopathy (TAO)
Prospective cross-sectional study
Choroidal thickness was measured with enhanced-depth imaging optical coherence tomography (EDI-OCT), in 104 eyes of 52 Chinese TAO patients and 52 eyes of 26 healthy subjects, at the macular central 2mm region and peripapillary region. Choroidal thickness measurements were compared between eyes with TAO (n=104) and without TAO (i.e. controls, n=52). Multivariate linear regression was used to evaluate the association of subfoveal choroidal thickness with systemic and ocular variables in TAO eyes.
The choroidal thickness was significantly increased from 2mm nasal to 2mm temporal the fovea, and from 2mm superior to 1mm inferior to the fovea when comparing TAO with control eyes (P < 0.05 at all 1mm interval locations). There was no significant difference in choroidal thickness at 2mm inferior to the fovea (P = 0.094) and 4 quadrants of the peripapillary region (superior, P = 0.096; nasal, P = 0.732, inferior, P = 0.179; temporal, P = 0.052). In multivariate analysis, thinner subfoveal choroidal thickness was associated with increasing exophthalmos (P = 0.043), decreasing visual acuity (P = 0.017), increasing age (P = 0.040) and increasing axial length (P < 0.001). The clinical activity score was not significantly associated with the change in choroidal thickness in TAO patients (P=0.239).
The choroidal thickness of TAO patients was increased in the macular, but not the peripapillary regions. Decrease in subfoveal choroidal thickness of TAO patients was associated with increase in exophthalmos and decrease in visual acuity. The subfoveal choroidal thickness could be a potential imaging marker in the assessment of TAO patients.