Macular hole and autologous internal limiting membrane transplantation

Session Details

Session Title: Free Paper Session 12: Imaging I

Session Date/Time: Friday 08/09/2017 | 14:30-16:00

Paper Time: 15:42

Venue: Room 111

First Author: : N.Semenova INDONESIA

Co Author(s): :    V. Akopyan   E. Gurova   E. Sokolova                       

Abstract Details


Swept-source optical coherence tomography (SS-OCT) with a wavelength of 1050-nm has allowed greater imaging depth and breadth. Therefore, SS-OCT provides clear visualization and segmentation of the macular choroid. Numerous studies assessed subfoveal choroidal thickness (CT) in healthy and diseased eyes with spectral domain OCT. However, the influence of demographic, systemic and ocular factors on CT is still discussed. Furthermore, only few studies described choroid topography measured with SS-OCT in normal adult population. The purpose of this study was to evaluate macular CT in population related to potentially influencing factors.


Cross-sectional population study. Lomonosov Moscow State University.


A total of 105 participants (105 eyes) with no history of eye disease had CT measured with SS-OCT (DRI OCT Triton, Topcon). Macular zone 7x7 mm was scanned (512x256 B-scans), CT assessed in fovea, superior, inferior, temporal and nasal para- and perifovea. Mean macular CT in all 9 sectors is calculated. Body mass index (BMI), spherical equivalent refraction and systemic diseases (arterial hypertension, diabetes mellitus, sleeping apnea) were taken into account.


The thickest choroid was observed in superior parafovea (28986 µm), fovea (29093 µm) and superior perifovea (28784 µm). Univariate analysis didn’t reveal an association of foveal CT or mean macular CT with sex (R = 0,16, p = 0,108 and R = 0,04, p = 0,75, respectively) and refraction (R = 0,13, р = 0,17 and R = -0,007, р = 0,95). Foveal CT and mean macular CT were negatively correlated with age (R = -0,517, р < 0,0001 and R = -0,56, р = 0,0001, respectively) and BMI (R = -0,271, р = 0,005 and R = -0,245, р = 0,012). Each of the systemic disease was independently associated with thinner CT, both mean macular and foveal. Among all systematic and ocular factors included in the multiple regression analysis, only age and refraction were related to foveal and mean macular CT.


The present study describes macular CT topographic variations in healthy eyes. Taking into account association with age, this study suggests “normal” CT range measured with swept-source OCT for 3 age groups. Foveal CT: 253-449 µm for age 20-39, 171-371 µm for age 40-59, 142-283 µm for age 60 and older; mean macular CT: 224-376 µm for age 20-39, 161-317 µm for age 40-59, 120-234 µm for age 60 and older.

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