Session Title: Free Paper Session 12: Imaging I
Session Date/Time: Friday 08/09/2017 | 14:30-16:00
Paper Time: 15:00
Venue: Room 111
First Author: : K.Schaal UK
Co Author(s): : M. Munk I. Wyssmueller L. Berger M. Zinkernagel S. Wolf
The ability to detect changes secondary to diabetic retinopathy using swept source optical coherence tomography angiography (SS-OCT-A) was compared with ETDRS severity grading based on conventional colour fundus imaging.
Patients with the diagnosis of diabetes were imaged with SS-OCT-A and colour fundus fotos and evaluated in a retrospective cross-sectional study in a university hospital setting.
Patients with the diagnosis of diabetes (Type I and II) were imaged using a 100 kHz SS-OCT-A instrument (Carl Zeiss Meditec Inc., Dublin, CA). The 3x3 and 12x12 mm cube feature was used to image the posterior pole. Two graders assessed the ETDRS severity level on colour fundus images. SS-OCT-A images were graded separately for features of diabetic retinopathy, and the grading results between the two imaging modalities were compared.
30 patients (53 eyes) had SS-OCT-A and colour fundus fotos acquired on the same day with sufficient image quality and were eligible to enter the comparison study. Inter-grader reliability regarding ETDRS severity grading of colour fundus fotos was good (R=0.7). 25% of patients had proliferative diabetic retinopathy, with good agreement in neovascularization detection with both imaging modalities (kappa=0.6). Agreement in terms of IRMA detection was poor (kappa= 0.1). In 63% a definite IRMA was detected on OCT-A, but was missed on colour fundus fotos.
Agreement between colour fundus grading and OCT-A of diabetic retinopathy features varies depending on the feature examined. OCT-A can show vascular abnormalities, suggesting a more advanced state of diabetic retinopathy compared to ETDRS grading.