Session Title: Free Paper Session 12: Imaging I
Session Date/Time: Friday 08/09/2017 | 14:30-16:00
Paper Time: 14:48
Venue: Room 111
First Author: : T.Fiore JAPAN
Co Author(s): : M. Lupidi A. Cerquaglia D. Fruttini G. Coscas C. Cagini
To determine optical coherence tomography angiography (OCT-A) utility in detecting and quantifying vascular changes and foveal microvasculature modifications due to idiopathic epiretinal membrane syndrome (iERM).
25 eyes of 25 patients affected by iERM, imaged with Spectralis OCT-A, were retrospectively analyzed. Morphological changes of superficial (SCP) and deep (DCP) capillary plexuses were qualitatively analyzed and recorded on high-resolution OCT-A angiograms obtained through the Full-spectrum amplitude-decorrelation angiography (FS-ADA) algorithm. An automated micro-structural analysis of the foveal avascular zone (FAZ) metrics, vascular and avascular surfaces and vascular density were performed. Quantitative data of iERM patients were compared with a normative data set of 47 healthy eyes.
Morphological qualitative changes such as, perifoveal arcade disruption, nearly-complete disappearance of FAZ, FAZ stretching and vascular flow interruption were observed in iERM eyes, whereas no abnormalities were found in healthy eyes. In iERM group, FAZ perimeter, vascular surface and vascular density were significantly decreased (p < 0.05). The avascular surface resulted increased (p < 0.05) in both SCP and DCP in the study group. FAZ surface was decreased in both plexuses of iERM eyes, even though these data were statistically significant (p < 0.05) only in SCP. Inverse linear correlation was demonstrated between central macular thickness and FAZ surface.
Spectralis OCT-A allowed a fast and depth-resolved visualization of vascular modifications occurring in iERM and may represent an objective method for monitoring and quantifying disease progression and also to foresee the functional response to the surgical treatment.