Optical coherence tomography angiography findings in retinal vein occlusion treated with anti-vascular endothelial growth factor

Session Details

Session Title: Free Paper Session 11: Vascular Diseases & Diabetic Retinopathy III

Session Date/Time: Friday 08/09/2017 | 11:00-12:30

Paper Time: 12:12

Venue: Room 114

First Author: : S.Yu SOUTH KOREA

Co Author(s): :    D. Kim   E. Kim                          

Abstract Details

Purpose:

To analyze patients with retinal vein occlusion using optical coherence tomography angiography (OCT-A) before and after anti-vascular endothelial growth factor (VEGF) therapy.

Setting:

Department of Ophthalmology, Kyung Hee University Hospital, Seoul, Korea

Methods:

Retrospective review of retinal vein occlusion with secondary macular edema patients treated with anti-VEGF and a minimum follow-up of 3 months between May 2016 and January 2017. Best-corrected visual acuity (BCVA), central retinal thickness (CRT) were assessed before and after treatment. The vascular change and nonperfused areas were evaluated with OCT-A.

Results:

The study analyzed 40 eyes of 40 patients (mean ages, 65.4 years), including 11 cases of central RVO, 23 cases of branch RVO and 6 cases of hemi-central RVO. All patients received anti-VEGF treatment of RVO with secondary macular edema at least once more intravitreal injection. The mean follow-up period was 5.5 months. After treatment, the logMAR BCVA significantly improved from 0.51±0.13 to 0.28±0.17 (p<0.01) and mean central retinal thickness significantly decreased from 405.13±142.0µm to 294.50±102.73µm (p<0.01). The perifoveal capillary disruption, the number of intraretinal cyst and venous dilatation in retinal superficial and deep capillary layers was significantly decreased after treatment using OCT-A. The nonperfused areas of after treatment was significantly decreased rather than baseline.

Conclusions:

The study showed reduction of non-perfused areas and improvement of retinal vascular flow after anti-VEGF treatment on OCT-A. OCT-A was effective and non-invasive diagnostic tool for RVO with secondary macular edema especially observing changes in the area of the nonperfused areas due to ischaemia.

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