Association between retinal vein occlusion and an increased risk of acute myocardial infarction: A 13-year population-based follow-up study

Session Details

Session Title: Free Paper Session 11: Vascular Diseases & Diabetic Retinopathy III

Session Date/Time: Friday 08/09/2017 | 11:00-12:30

Paper Time: 11:42

Venue: Room 114

First Author: : Y.Chen TAIWAN

Co Author(s): :    S. Sheu                             

Abstract Details

Purpose:

To investigate a possible association between retinal vein occlusion (RVO) and increased risk of acute myocardial infarction (AMI) development.

Setting:

A population-based retrospective cohort study, using the whole population National Health Insurance Database (NHID) from 1st January, 2001 to 31st December, 2013 in Taiwan.

Methods:

37573 subjects with RVO were enrolled into the RVO group and 150292 subjects without RVO into the comparison group. The comparison group consisted of randomly-selected individuals from NHID, matched with the RVO group based on age and gender at a ratio of 1:4. Kaplan-Meier curves were used to compare the cumulative incidence of AMI between the two groups. Cox regression analysis was used to estimate the crude and adjusted hazard ratio (HR) of AMI. Confounding adjustment was performed for age, gender, and systemic comorbidities (i.e. diabetes, hypertension, hyperlipidemia, atrial fibrillation and congestive heart failure).

Results:

The mean age of the cohort was 64.9±11.6 years. There were slightly more males than females (51.1% vs. 48.9%). Significantly higher proportions of RVO patients had diabetes, hypertension, hyperlipidemia, congestive heart failure, and atrial fibrillation than the comparison group. A log-rank test comparing Kaplan-Meier curves of the two groups revealed a significant difference in their cumulative incidence of AMI (p-value<0.0001). In the univariate analysis by Cox model, RVO patients had a significantly higher risk of AMI (crude HR=1.59; 95% confidence interval 1.48 to 1.70). After adjustment, results remained significant (adjusted HR=1.36; 95% confidence interval 1.27 to 1.46). When RVO group was divided into branch retinal vein occlusion (BRVO) and central retinal vein occlusion (CRVO) and analyzed separately, both groups had signify higher hazard of developing AMI (p-value<0.0001). And, CRVO patients had signify higher risks of AMI compared with BRVO patients (p-value=0.0002).

Conclusions:

People with RVO are at significantly greater risk of developing AMI than those without RVO.

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