Analysis of neurodegenerative signs in SD-OCT scans in type 2 diabetic patients without diabetic retinopathy

Session Details

Session Title: Free Paper Session 11: Vascular Diseases & Diabetic Retinopathy III

Session Date/Time: Friday 08/09/2017 | 11:00-12:30

Paper Time: 11:24

Venue: Room 114

First Author: : J.Mackiewicz POLAND

Co Author(s): :    M. Olejniczak   M. Jasielska   A. Prokopiuk   J. Tomaszewska                    

Abstract Details

Purpose:

The purpose of the study was to evaluate retinal thickness and nerve fiber layer thickness in the macula and around the optic disc in spectral – domain optical coherence tomography (SD-OCT) images in type 2 diabetic patients without any signs of diabetic retinopathy.

Setting:

Department of Vitreoretinal Surgery of Medical University of Lublin, Poland

Methods:

A total number of 357 eyes have been examined. Diabetic patients group (DG) consisted of 201 eyes and control group (CG) of 156 eyes. Refraction, distance and near visual acuity, intraocular pressure, clinical examination of the anterior and posterior segment were performed in all patients. Only patients without any clinical signs of diabetic retinopathy were included into study. SD-OCT (Copernicus, Optopol) was carried out to evaluate retinal and nerve fiber layer thickness in the macula and around the optic disc. Results were correlated with the visual acuity, age, duration of the diabetes and the arterial hypertension. An ANOVA statistical analysis was performed.

Results:

The mean average retinal thickness was 207,7 ± 37 um and 213,9 ± 25 um in DG and CG respectively. The difference between two groups was statistically significant. The mean average nerve fiber layer thickness in the macula was 7,2 ± 1,8 um in DG and 8,2 ± 4,7 um in CG and the difference between two groups was statistically significant as well. The mean average nerve fiber layer thickness around the optic disc was thinner in all four segments in DG , statistically significant in upper and lower segments. Thinning of the retina and nerve fiber layer in the macula and around the optic disk along with the age was observed in both groups, however was greater in DG and the difference between two groups was statistically significant. Regarding to visual acuity, in both groups, it was decreasing along with the thinning of the retinal and nerve fiber layer thickness in the macula, which was also statistically significant. Analysing the correlation between the duration of diabetes mellitus and arterial hypertension, there were no statistically significant differences in the results.

Conclusions:

Our results support the presence of a neurodegenerative component in eyes of diabetic subjects. The SD-OCT is a simple and non-invasive exam that maybe helpful tool for identifying early, pre-clinical signs of neurodegeneration process in diabetic patients.

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