Evaluation of photoreceptors and choriocapillaris in patients with birdshot chorioretinopathy

Session Details

Session Title: Free Paper Session 10: Uveitis

Session Date/Time: Friday 08/09/2017 | 11:00-12:30

Paper Time: 11:30

Venue: Room 111

First Author: : R.Forte FRANCE

Co Author(s): :    M. Saleh   F. Aptel   M. Mauget-Faysse   C. Chiquet                    

Abstract Details

Purpose:

To assess the status of the cone photoreceptors using adaptive optics (AO) imaging in patients with birdshot chorioretinopathy (BSCR) and to study their relationship with visual function and the optical coherence tomography (OCT) morphology of the central retina.

Setting:

Consecutive patients in university hospital ophthalmology service.

Methods:

13 patients with BSCR were studied using standard automated perimetry, fluorescein angiography, indocyanine green angiography (ICGA), AO imaging (Imagine Eyes, Orsay, France), spectral domain OCT and angio OCT (OCT-A, Heidelberg Engineering, Heidelberg, Germany). For AO analysis, the BSCR group was compared to a group of 12 healthy controls matched for age, sex and refractive error.

Results:

After excluding low quality AO images, 12 eyes (10 patients, 7 females, mean age 53.5±10.8 years) were analysed. BCVA was 0.01±0.03 LogMAR. Cone density in BSCR group was significantly smaller than in the control group (p<0.001) and was associated with the duration of the disease (Spearman’s rho -0.8, p=0.001), and with the presence of vasculitis, capillary leakage, disruption of the ellipsoid band and macular capillary abnormalities at OCT-A (p<0.05). Cone density at 1.5° was not significantly associated with BCVA, mean sensitivity deviation, foveal sensitivity threshold, presence of choroidal hypocyanescent spots at ICGA, or the presence of suprachoroidal fluid.

Conclusions:

BSCR can result in a reduction of cone density and with macular capillary abnormalities. These abnormalities are associated with retinal vascular inflammation.

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