Diabetic retinopathy phenotypes of progression to macular edema. Pooled analysis from independent longitudinal studies of up to two years duration

Session Details

Session Title: Free Paper Session 7: Vascular Diseases & Diabetic Retinopathy II

Session Date/Time: Thursday 07/09/2017 | 14:30-16:00

Paper Time: 15:48

Venue: Room 117

First Author: : M.Ribeiro PORTUGAL

Co Author(s): :    J. Cunha Vaz   M. Costa   R. Simo                       

Abstract Details


To test the risk of progression to macular edema of different phenotypes of NPDR.


Pooled data analysis of four independent prospective longitudinal studies of mild nonproliferative diabetic retinopathy (NPDR).


Data from a total of 882 patients with mild NPDR, ETDRS grades 20 and 35, with no prior laser treatment, enrolled in four separate prospective longitudinal studies during 2007-2015 using the same reading centre and with the same inclusion criteria was pooled for analysis. One eye pre patient was followed for up to 2 years until development of macular edema. Ophthalmological examinations included best corrected visual acuity, colour fundus photography (CFP) and optical coherence tomography (OCT). They were performed at baseline, 6 months, with the last visit at 12 or 24 months, depending on the study. The eyes/patients were classified as belonging to Phenotypes A, B, and C on the basis of OCT central subfield thickness and microaneurysm activity


A total of 882 eyes/patients performed the 12 or 24 month visit or developed macular edema. Of these 882 eyes/patients that completed the different studies, 103 developed macular edema. Fourteen from Phenotype A (14 of 466: 3.0%), 48 from Phenotype B (48 from 164: 29.3%) and 41 from Phenotype C (41 from 252: 16.3%). Eyes/patients from Phenotypes B and C showed much higher risks for macular edema development comparing with Phenotype A (OR: 10.5 (5.5-20.2) p<0,001; OR- 5.6 (3.0-10.2), p<0.001, respectively).


NPDR phenotypes based on microaneurysm turnover and central macular thickness OCT at the 6 months visit using CFP and OCT, both non-invasive examinations, identify the eyes at risk of developing macular edema.

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