Diabetic retinopathy phenotypes of progression to macular edema. Pooled analysis from independent longitudinal studies of up to two years duration

Session Details

Session Title: Free Paper Session 7: Vascular Diseases & Diabetic Retinopathy II

Session Date/Time: Thursday 07/09/2017 | 14:30-16:00

Paper Time: 15:48

Venue: Room 117

First Author: : M.Ribeiro PORTUGAL

Co Author(s): :    J. Cunha Vaz   M. Costa   R. Simo                       

Abstract Details

Purpose:

To test the risk of progression to macular edema of different phenotypes of NPDR.

Setting:

Pooled data analysis of four independent prospective longitudinal studies of mild nonproliferative diabetic retinopathy (NPDR).

Methods:

Data from a total of 882 patients with mild NPDR, ETDRS grades 20 and 35, with no prior laser treatment, enrolled in four separate prospective longitudinal studies during 2007-2015 using the same reading centre and with the same inclusion criteria was pooled for analysis. One eye pre patient was followed for up to 2 years until development of macular edema. Ophthalmological examinations included best corrected visual acuity, colour fundus photography (CFP) and optical coherence tomography (OCT). They were performed at baseline, 6 months, with the last visit at 12 or 24 months, depending on the study. The eyes/patients were classified as belonging to Phenotypes A, B, and C on the basis of OCT central subfield thickness and microaneurysm activity

Results:

A total of 882 eyes/patients performed the 12 or 24 month visit or developed macular edema. Of these 882 eyes/patients that completed the different studies, 103 developed macular edema. Fourteen from Phenotype A (14 of 466: 3.0%), 48 from Phenotype B (48 from 164: 29.3%) and 41 from Phenotype C (41 from 252: 16.3%). Eyes/patients from Phenotypes B and C showed much higher risks for macular edema development comparing with Phenotype A (OR: 10.5 (5.5-20.2) p<0,001; OR- 5.6 (3.0-10.2), p<0.001, respectively).

Conclusions:

NPDR phenotypes based on microaneurysm turnover and central macular thickness OCT at the 6 months visit using CFP and OCT, both non-invasive examinations, identify the eyes at risk of developing macular edema.

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