Segmented swept source optical coherence tomography angiography in Coats’ disease: New perifoveal microvascular changes in the healthy eye and correlation with disease stage in the affected one

Session Details

Session Title: Free Paper Session 7: Vascular Diseases & Diabetic Retinopathy II

Session Date/Time: Thursday 07/09/2017 | 14:30-16:00

Paper Time: 14:42

Venue: Room 117

First Author: : K.Chwiejczak UK

Co Author(s): :    S. Biswas   F. Stringa   A. Papayannis   E. Tsamis   P. Stanga                 

Abstract Details


Verify whether segmented swept source Optical Coherence Tomography Angiography (sSS OCT-A) can reveal any new clinically significant microvascular findings in the macula of the healthy eyes in patients with unilateral Coat’s disease and their correlation to stage of disease in the affected eye.


Manchester Vision Regeneration (MVR) Lab at Manchester Royal Eye Hospital & NIHR/Wellcome Trust Manchester CRF and Manchester Royal Eye Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom.


Patients (Mean Age: 11.5± 4.18, range 7-18 years, 1 female and 10 males) with unilateral Coats’ disease (stages 2A, stage 2B, and previously treated stage 3). Eyes underwent sSOCT-A (DRI Triton®, Topcon Corporation, Tokyo, Japan, software version: IMAGEnet® 1.19) 3x3mm macular fovea-centreed scans. Scans were semi-automatically (manual changes to the segmentation boundaries were carried out if necessary) segmented: superficial (SP) and deep (DP) neurovascular plexuses, outer retina and choriocapillaris and findings analysed on a per plexus basis. Surface area (A), horizontal(H) and vertical (V) diameters of foveal avascular zone (FAZ) were assessed by 2 independent observers and Mean Values calculated. Vascular density (VD) was measured for the SP and DP in the foveal (1) and parafoveal (4) areas and the Mean Value for the 5 areas calculated.


For SP: A = 83.82 to 428.78 μm2 (Mean Value: 211,416 +/- 126.77μm2), V = 285 to 896μm (Mean Value: 563.77 +/- 218.98μm); H = 234 to 716.5μm (Mean Value: 504.14 +/- 144.14μm) and VD = 50.2 to 72,8 (Mean Value: 58.69 +/- 6.7). For DP: A = 83.85 to 289.73 μm2 (Mean Value: 178,11+/- 79.05μm2), V = 231.5 to 606μm (Mean Value 427.86 +/- 105.3μm); H = 414 to 596μm (Mean Value :474.9 +/- 86.85 4μm) and VD = 29.8 to 44.2 (Mean Value: 38.02 +/- 4.8μm). There was no correlation between imaged parameters and the stage of disease in the affected eye. We observed peri-FAZ changes in the SP: temporal pruning (2 patients, stage 3), vascular loops (1 patient, stage 3), pruning and loops (2 patients, stage 3) and crossing of vessels (1 patient, stage 2b).


Surface area and diameters of FAZ, as well as VD, varied largely between individuals. Clinically healthy fellow eyes show on sSS OCT-A distinct perifoveal microvascular changes in the SP. There seems to be no correlation between the reported microvascular changes in the healthy eye and stage of disease in the affected eye.

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