Session Title: Free Paper Session 5: Anterior/Posterior Segment Surgery
Session Date/Time: Thursday 07/09/2017 | 11:00-12:30
Paper Time: 11:42
Venue: Room 117
First Author: : M.Demir TURKEY
Co Author(s): : D. Guven S. Sendul S. Tiryaki Demir H. Kacan G. Arslan
To inspect the macular flow area and vessel density in optical coherence tomography (OCT) angiography in diabetic patients and healthy subjects.
Sisli Etfal Training and Research Hospital, Department of Ophthalmology Istanbul/Turkey
This prospective study included fiftyfour eyes of 27 (14 females, 13 males) diabetic patiens (Diabetic group) and 32 eyes of 16 (7 females, 9 males) healthy (Control goup) subjects. Examination of BCVA, intraocular pressure (IOP), slit lamp and steroscopic retinal were performed in all participants. Diabetic group included patients with treated panretinal laser photocoagulation for proliferative diabetic retinopathy (PDR) with or without grid laser treatment due to diabetic macular edema, and had nonproliferative diabetic retinopathy (NPDR) that no had laser treatment. Also the patients who received laser treatment were divided to subgroups according to; level of best corrected visual acuity (BCVA, in Snellen) ≤0.2, or >0.2, received grid treatment and central macular thickness (CMT) ≤300 µm or>300 µm. The central macular flow area (3.143 mm2, a circle with 2 mm radial length and centreed on fovea), superficial foveal and parafoveolar vessel density (%), and CMT were measured using optical coherence tomography angiography (RTVue XR Avanti; Optovue, Inc, Fremont, California, USA). The patients with optic atrophy, retinal vein or artery occlusion, undergoing vitrectomy and choroid neovacularization were excluded. The data of participants were analysed using Two sample t test and Pearson’s correlation. P value less than 0.05was considered statistically significant.
The mean age were 60.8±8.1 and 59.8±11.1 (p=0.382) years old and the mean BCVA were 0.42±0.32 and 0.86±0.166 (p<0.00001), CMT were 313.3±119.5;250.4±26.7 µm (p=0.0002) in diabetic and in control groups, respectively. The diabetic group included 34 eyes with treated panretinal laser photocoagulation for PDR that 10 eyes of them als received grid treatment, and 20 eyes with NPDR. The mean macular flow area were 1.29±0.20 and 1.36±0.16 mm2 (p=0.044) in centre of macula, the mean foveal vessel density were 31.6±6.9% and 31.2±5.9% (p=0.374), the mean parafoveal vessel density were 48.3±5.4% and 51.8±5.2% (p=0.002) in the diabetic and control groups, respectviely. The mean of BCVA, flow area, and parafoveal vessel density was higher in patients with NPDR than patients with PDR (p<0.05). Macular flow area had moderate negative correlation with parafoveal vessel density (r=-0.410, p<0.00001, r=-0.481, p<0.00001), but no correlation with foveal vessel density (r=-0.031, r<0.00001) in patients with PDR. The correlation of flow area with foveal and parafoveal vessel density were (r=0.048, p<0.00001; r=0.037, p<0.00001; r=0.0048, p<0.00001), in patients with received grid laser, respectively.
The mean values of macular flow area and parafoveal vessel density were lower in the diabetic patients than healthy subjects. The mean values of flow area and parafoveal vessel density were higher in healthy subjects than patients with PDR. Also the mean flow area and parafoveal vessel density were lower in PDR patients than NPDR. The macular flow area had moderate negative correlation with parafoveal vessel density in patients with PDR. The patients with PDR and CMT>300 µm, macular flow area and foveal vessel density was higher significantly than patients with CMT<300 µm. The flow area, foveal and parafoveal vessel density were similar patients with BCVA≤0.2 or BCVA>0. 2 in patients with PDR. Macular flow area showed a stronge correlation with parafoveal vessel density and moderate correalation with foveal vessel density in all participants. There was no effect of grid laser treatment on macular flow area and foveal vessel density