Prevalence and incidence of age-related macular degeneration in Europe – a systematic review and meta-analysis

Session Details

Session Title: Free Paper Session 4: AMD II

Session Date/Time: Thursday 07/09/2017 | 11:00-12:30

Paper Time: 11:42

Venue: Room 111

First Author: : J.Li GERMANY

Co Author(s): :    T. Welchowski   M. Schmid   F. Holz   R. Finger                    

Abstract Details


Age-related macular degeneration (AMD) is the main cause of blindness in high income countries. To support health service planning in an ageing population, we performed a comprehensive situation analysis for AMD in Europe including a systematic literature review and meta-analysis of prevalence and incidence data, as well as a forecast until 2050 based on population ageing.


Systematic review of the literature and situation analysis using Eurostat data


PubMed, EMBASE and Web of Science databases were searched for population-based prevalence and incidence studies published between 1996 and 2016, for the five most populated countries in Europe: France, Germany, Italy, Spain and United Kingdom. Literature search and data analysis were performed according to the international guideline for systematic literature searches and meta-analysis of observational studies in epidemiology (MOOSE). Data were meta-analyzed using a random effects model.


Of 1,735 abstracts screened, 18 national studies and one multi-national study reporting prevalence as well as two national studies reporting incidence of AMD met the inclusion criteria, presenting data from 30,633 adults. Thirteen prevalence studies were eligible for meta-analysis. As only two incidence studies met inclusion criteria, no meta-analysis was performed for incidence data. Among adults aged 60 years and older, pooled prevalence of early and intermediate AMD was estimated 41.1% (31.2-51.8%), whereas late AMD was 3.6% (2.9-4.5%). Based on Eurostat Population data, a projection of future trends is provided.


AMD is a common ophthalmological condition in older adults, affecting nearly half of the population above 60 years of age in Europe. Moreover, prevalence is expected to increase considerably. Facing an ageing population, expansion of research on prevention and additional provision of health care resources for eye healthcare provision is needed.

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