Multimodal evaluation of the fellow eye of patients with retinal angiomatous proliferation

Session Details

Session Title: Free Paper Session 4: AMD II

Session Date/Time: Thursday 07/09/2017 | 11:00-12:30

Paper Time: 11:12

Venue: Room 111

First Author: : A.Martins PORTUGAL

Co Author(s): :    C. Farinha   M. Raimundo   M. Marques   J. Marques   J. Cunha-Vaz   R. Silva              

Abstract Details

Purpose:

To detect imaging markers in fellow-eye of patients with RAP and compare them with AMD and healthy controls.

Setting:

Ophthalmology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal

Methods:

Multimodal cross-sectional evaluation. Included eyes were divided into 4study groups: controls, early/intermediate AMD, fellow-eyes of RAP, and RAP. Patients were evaluated with SD-OCT, EDI-OCT and OCT-Angiography (OCT-A). OCT-A images were processed to generate density maps of vascular perfusion of the superficial, deep retinal plexus and the choriocapillaris layer. The thickness of the outer nuclear layer (ONL) and choroid were manually assessed.

Results:

We included 135eyes of 100patients (51controls, 30AMD, 42RAP and 12fellow-eyes). The fellow-eyes showed a significantly lower vascular perfusion in all layers, than AMD groups (all p<0.02). Additionally, these eyes showed a significantly thinner nasal ONL than controls and AMD eyes (all p<0.05). The central and peripheral choroid thickness, were significantly lower in fellow-eyes and RAP eyes, when compared to controls and AMD (all p<0.03).

Conclusions:

We present the first report on the OCT-A analysis of the fellow-eye of RAP. The reduced vascular perfusion and vessel density observed not only in RAP eyes but also in fellow-eyes contributes, in association with the lower thickness of the ONL and the choroid, to a wider characterization as a distinctive phenotype.

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