Rapid Fire Saturday 19 May 08:00 - 09:32 Salle des Princes
I. Solomatin, J. Gertnere,
LATVIA
Therapy with Avastin for age-related macular degeneration
Purpose: The aim of the study was to evaluate the retinal thickness and structure by optical coherence tomography (OCT) in the patients with choroidal neovascularization (CNV) due to age-related macular degeneration (ARMD) before and after the treatment with Avastin. Methods: 72 patients (49 females and 23 males), 64 to 92 years old (mean 74,8) was examined. In a retrospective study was analyzed 72 eyes with subfoveal occult CNV associated with AMD. Snellen visual acuity ranged between 20/800 - 20/40. All patients with fluorescein angiographic evidence of subfoveal occult CNV secondary to ARMD were treated with avastin. The optic coherence tomographic measurement (Stratus OCT, Karl Zeiss Meditec) was performed before treatment and at 4, 12 and 24 weeks after the treatment. Results: 72,2% of the eyes (52 eyes) were stable in visual acuity. 13,9% (10 eyes) of the eyes gained two or more lines, 13,9% (10 eyes) of the eyes lost two or more lines. Severe vision loss (decrease of three or more lines) was seen in 6,9% of the eyes (5 eyes) due to serous or hemorragic retinal pigment epithelial detachment. Before the treatment the fovea was significantly thicker in 57 eyes. The following therapy, the retinal thickness has decreased in height. The neurosensory detachment before the avastin treatment was established in 39 (54,1%) eyes, after treatment in 21 (29,1%) eyes. The fibrovascular proliferation before the procedure was determined in 69 (95%) eyes, after treatment in 51 (70,8%) eyes. Cystoid macular edema before and after treatment was established in 15 (20%) and 7 (10%) eyes. After treatment choroid optical reflectivity was on the increase. Conclusions: The treatment with Avastin injection seems to be benefit in clinical activity decrease in eyes with occult CNV associated with ARMD.
